Course Descriptions BIOC 5001   Special Topics in Biochemistry & Molecular Biology
CREDIT HOURS: 3
Students interested in topics not covered in formal classes may ask the department for special classes to meet their needs. The fields in which the department can offer instruction are reflected in the list of faculty research areas.

BIOC 5010   Bioinformatics
CREDIT HOURS: 3
This course presents the theory and practice of bioinformatics. Topics include: rates of mutations, sequence alignment, database searching, phylogenetic analysis, bioinformatic tools for analyzing gene, genomes and proteins.
FORMAT:
  • Lecture
  • Lab

FORMAT COMMENTS: regular computer-based labs
LECTURE HOURS PER WEEK: 3
EXCLUSIONS: BIOC 4010.03

BIOC 5305   Mechanisms of Signal Transduction
CREDIT HOURS: 3
The goal of this course is to introduce key concepts of signal transduction. Topics include regulation of cell signalling by receptors and protein kinases, lipids in signalling, cell metabolism, apoptosis, autophagy, cell cycle and cell signalling in disease.
EXCLUSIONS: BIOC 4305

BIOC 5307   Current Topics in Molecular and Cell Biology of Lipids
CREDIT HOURS: 3
Explores mechanisms and regulation of lipid metabolism, trafficking, and cell signaling. Includes sections on lipids in the central nervous system, methods of lipid analysis, and lipids in disease. Emphasis is given to the evaluation of original data and critical reading of current literature. Evaluation is based on seminar presentations, an essay, and short home assignments.
FORMAT:
  • Seminar
  • Discussion

FORMAT COMMENTS: Seminar/discussion 3 hours
PREREQUISITES: Instructor's consent.

BIOC 5308   Molecular Mechanisms of Complex Diseases
CREDIT HOURS: 3
The objective of this seminar course is to familiarize students with the molecular mechanisms that are involved in human diseases. The course will emphasize Metabolic Syndrome which is comprised of cancer, diabetes and cardiovascular diseases and clinical applications of molecular signalling. Specific areas that are covered in detail include the role of tumor suppressors, oncogenes, cell metabolism and epigenetic events that give rise to disease. The use of animal models to study the complex interplay between environment and molecular homeostasis will also be discussed.
FORMAT COMMENTS: Essay, oral presentation based on essay, journal article presentation, take home assignments

BIOC 5309   Advances in Cardiovascular Biochemistry
CREDIT HOURS: 3
Using primary literature, this course covers biochemical mechanisms underlying cardiac physiology and pathology. Topics include: myocyte action potential biochemistry; cardiac conducting systems; sarcolemmal calcium signaling; cytoskeletal assembly; endothelium-cardiomyocyte crosstalk; metabolite utilization; mitochondrial energy metabolism; pathological signaling pathways and their remodeling; and, biochemistry of congenital heart disease.
FORMAT: Lecture

BIOC 5403   Genes and Genomes
CREDIT HOURS: 3
This course discusses the organization of genes into genomes. It deals with (i) genetic material in nuclear and organellar genomes, (ii) components of genomes that are not genes, (iii) methodology of genomics and proteomics, and (iv) genetic organization and higher order chromosomal structure and function.
FORMAT: Lecture
LECTURE HOURS PER WEEK: 3
EXCLUSIONS: BIOC 4403.03

BIOC 5404   Gene Expression
CREDIT HOURS: 3
This course is centered around the central dogma that genetic information is passed from DNA to RNA to protein. We focus on the different mechanisms that regulate this flow of information in prokaryotic and eukaryotic cells. Specific topics include transcription, translation, chromatin, epigenetics, and non-coding RNA.
FORMAT: Lecture
LECTURE HOURS PER WEEK: 3
EXCLUSIONS: BIOC 4404.03

BIOC 5501   Medical Biotechnology
CREDIT HOURS: 3
This course covers the fundamental principles of biotechnology from a medical perspective. Topics covered include: recombinant DNA technology, DNA sequencing, DNA microarray, antibody and polymerase-chain reaction-based applications, production of transgenic organisms, potential applications for embryonic stem cell and nuclear transfer cloning, business and legal aspects of biotechnology.
FORMAT:
  • Lecture
  • Discussion

FORMAT COMMENTS: presentations
EXCLUSIONS: BIOC 4501.03

BIOC 5503   Pathobiology of Cancer
CREDIT HOURS: 3
This course will examine the basic molecular and cellular biology of carcinogenesis and tumor pathobiology, as well as emerging topics in cancer genomics, diagnosis and treatment. The clinical aspects of cancer management will also be highlighted, including surgery, radiation and chemotherapy.
FORMAT:
  • Lecture
  • Discussion

FORMAT COMMENTS: student presentations
LECTURE HOURS PER WEEK: 3
CROSS-LISTING: PATH 5040.03, MICI 5040.03

BIOC 5700   Proteins
CREDIT HOURS: 3
Our theme is the relationship between structure and function. The kinetic and thermodynamic determination of the protein fold is explored. Specific details of how form determines function in binding other molecules both small and large, in membranes, and in energy transduction are provided. Protein evolution and turnover are examined.
FORMAT: Lecture
LECTURE HOURS PER WEEK: 3
EXCLUSIONS: BIOC 4700.03

BIOC 5701   Enzymes
CREDIT HOURS: 3
Fundamental principles of enzyme catalysis and its regulation are examined. Topics include enzyme kinetics, enzyme inhibition and inactivation, isotope effect measurements, site-directed mutagenesis, and the active site architecture and transition state stabilization of selected enzymes. Classic and current papers in the literature are reviewed and the experimental and conceptual approaches are critically appraised.
FORMAT:
  • Lecture
  • Seminar

FORMAT COMMENTS: problem sets, essay
LECTURE HOURS PER WEEK: 3
EXCLUSIONS: BIOC 4701

BIOC 5702   Biophysical Characterization of Macromolecules
CREDIT HOURS: 3
This course covers methods allowing determination of sub-molecular and atomic-level structure and dynamics of biomacromolecules in physiological settings (e.g. solution-state or lipid bilayers) including: fluroescence, electronic and vibrational circular dichroism and NMR spectroscopy; light vs. X-ray vs. neutron scattering; and, single molecule methods.
FORMAT: Lecture
CROSS-LISTING: CHEM 5602.03
EXCLUSIONS: BIOC 4702.03, CHEM 4602.03

BIOC 5703   Structural Biology
CREDIT HOURS: 3
This course covers theoretical and practical aspects of determining and assessing the quality of atomic-resolution biomolecular structures. The underlying theory and applications of X-ray diffraction, NMR spectroscopy, and cryo-electron microscopy are discussed in detail.
FORMAT:
  • Lecture
  • Lab
  • Tutorial

FORMAT COMMENTS: Two lectures will be substituted with laboratory demonstrations in the NMR3 and X-ray diffraction facilities. Two-three review-based tutorials will be held.
LECTURE HOURS PER WEEK: 3
CROSS-LISTING: CHEM 5603.03
EXCLUSIONS: BIOC 4703.03, CHEM 4603.03

BIOC 5813   Biochemistry of Clinical Disorders
CREDIT HOURS: 3
This course is an introduction to the pathophysiology of disease. It provides the clinical and biochemical background to disease groups and system disorders and the laboratory approach to their diagnosis. Topics include cardiovascular, renal, gastrointestinal and hepatobiliary disorders, in addition to acid base, carbohydrate, lipid and amio acid disorders; endocrine and rheumatological diseases, as well as tumor markers and toxicology, blood and immune abnormalities.
FORMAT:
  • Lecture
  • Discussion

FORMAT COMMENTS: Lectures 3 hours per week. Assignments, midterm and final exam. Case discussions.
CROSS-LISTING: PATH 5013.03
EXCLUSIONS: PATH 5011.03 and PATH 5012.03, BIOC 4813.03

BIOC 5910X/Y    Biochemistry and Molecular Biology Seminar
CREDIT HOURS: 6
This course provides students with experience in the written and oral presentation of scientific data. Interactive faculty and peer feedback is used to hone students’ skills with an emphasis on both clarity of presentation and on the ability of students to discuss specialist topics in general terms.
FORMAT: Seminar
FORMAT COMMENTS: Computer-based assignments, presentations and attendance at Department Seminar

BIOC 5914   Scientific Communication in Biochemistry and Molecular Biology I
CREDIT HOURS: 3
This course provides students with experience in the written and oral presentation of scientific data. Interactive faculty and peer feedback is used to hone student skills with an emphasis on both clarity of presentation and on the ability of students to discuss specialist topics in general terms.
FORMAT:
  • Tutorial
  • Seminar

FORMAT COMMENTS: Computer-based assignments, presentations and attendance at Department Seminar
TUTORIAL HOURS PER WEEK: 2
EXCLUSIONS: BIOC 5910.06

BIOC 5915   Scientific Communication in Biochemistry and Molecular Biology II
CREDIT HOURS: 3
This course provides students with experience in oral presentation of scientific data and in organization of a scientific symposium. Interactive faculty and peer feedback is used to hone student skills with an emphasis on both clarity of presentation and on the ability of students to discuss specialist topics in general terms.
FORMAT:
  • Seminar
  • Other (explain in comments)

FORMAT COMMENTS: Other - Symposium Presentations, symposium organization and attendance at Department Seminar
EXCLUSIONS: BIOC 5910.06

BIOC 6701   Mechanistic Enzymology
CREDIT HOURS: 1.5
Enzymes from a variety of classes will be examined from an organic chemistry reaction mechanism perspective. The general principles of enzyme catalysis and the experimental approaches used to elucidate enzyme reaction mechanisms will be discussed. Applications and examples from the current literature will be critically appraised.
FORMAT: Lecture
FORMAT COMMENTS: group problem-based learning
LECTURE HOURS PER WEEK: 3
PREREQUISITES: Instructor's consent
CROSS-LISTING: CHEM 6458.015

BIOC 6702   Topics in High Resolution Nuclear Magnetic Resonance
CREDIT HOURS: 1.5
Advanced topics in high resolution liquid state nuclear magnetic resonance will be explored, including the quantum mechanical basis of the observables, product operator treatment of pulse sequences, 2D NMR pulse sequences, coherence selection and relaxation.
FORMAT: Lecture
FORMAT COMMENTS: assignments
LECTURE HOURS PER WEEK: 3
PREREQUISITES: Instructor's permission.
EXCLUSIONS: CHEM 6362.015